TPRKB Gene Summary [Human]
Enables protein kinase binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytosol and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 5. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | TPRKB |
| Official Name | TP53RK binding protein [Source:HGNC Symbol;Acc:HGNC:24259] |
| Ensembl ID | ENSG00000144034 |
| Bio databases IDs | |
| Aliases | TP53RK binding protein |
| Synonyms | 0610033G21Rik, 1810034M08Rik, CGI-121, DRWMS1, GAMOS5, LOC100910911, LOC103690067, mDRWMS1, RGD1309786, TP53RK binding protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TPRKB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinase binding protein CGI-121
- protein kinase binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TPRKB gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- EKC/KEOPS complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding