SPOCK2 Gene Summary [Human]
This gene encodes a protein which binds with glycosaminoglycans to form part of the extracellular matrix. The protein contains thyroglobulin type-1, follistatin-like, and calcium-binding domains, and has glycosaminoglycan attachment sites in the acidic C-terminal region. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | SPOCK2 |
| Official Name | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 [Source:HGNC Symbol;Acc:HGNC:13564] |
| Ensembl ID | ENSG00000107742 |
| Bio databases IDs | |
| Aliases | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 |
| Synonyms | AA407235, GCAP26, KIAA0275, mKIAA0275, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2, SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2, Testican-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPOCK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand domain pair
- extracellular matrix binding
- calcium ion binding
- signal peptide
- EFh
- protein binding
- KAZAL_FS
- unique protein domain
- glycosaminoglycan binding
- EFh_SPARC_EC
- TY
- Thyroglobulin-like domain
- Secreted protein acidic and rich in cysteine Ca binding region
- metalloendopeptidase inhibitor
- follistatin (FS) domain
- calcium binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- uterine serous papillary cancer
- survival
- backache
- systemic autoimmune syndrome
- doxorubicin induced cardiotoxicity
regulates
- MMP2
- endopeptidase
role in cell
- proliferation
- migration
- outgrowth
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
- perikaryon
- axons
- dendrites
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPOCK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse assembly
- regulation of cell differentiation
- extracellular matrix organization
- negative regulation of endopeptidase activity
- positive regulation of cell-substrate adhesion
- positive regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- extracellular matrix binding
- protein binding
- glycosaminoglycan binding
- calcium ion binding
- metalloendopeptidase inhibitor activity