Tprkb Gene Summary [Mouse]
Predicted to enable protein kinase binding activity. Predicted to be involved in tRNA threonylcarbamoyladenosine modification. Predicted to be located in cytoplasm. Predicted to be part of EKC/KEOPS complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome 5. Orthologous to human TPRKB (TP53RK binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Tprkb |
| Official Name | Tp53rk binding protein [Source:MGI Symbol;Acc:MGI:1917036] |
| Ensembl ID | ENSMUSG00000054226 |
| Bio databases IDs | |
| Aliases | Tp53rk binding protein |
| Synonyms | 0610033G21Rik, 1810034M08Rik, CGI-121, DRWMS1, GAMOS5, LOC100910911, LOC103690067, mDRWMS1, RGD1309786, TP53RK binding protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tprkb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinase binding protein CGI-121
- protein kinase binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tprkb gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- EKC/KEOPS complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding