ST6GAL2 Gene Summary [Human]
This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | ST6GAL2 |
| Official Name | ST6 beta-galactoside alpha-2,6-sialyltransferase 2 [Source:HGNC Symbol;Acc:HGNC:10861] |
| Ensembl ID | ENSG00000144057 |
| Bio databases IDs | |
| Aliases | ST6 beta-galactoside alpha-2,6-sialyltransferase 2 |
| Synonyms | beta galactoside alpha 2,6 sialyltransferase 2, C230064G14Rik, LOC100129665, mKIAA1877, SIAT2, ST6 beta-galactoside alpha-2,6-sialyltransferase 2, ST6Gal-II, ST6 β-galactoside α-2,6-sialyltransferase 2, β galactoside α 2,6 sialyltransferase 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ST6GAL2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- beta-galactoside alpha-2,6-sialyltransferase
- glycosyltransferase family 29
- sialyltransferase
- enzyme
- protein binding
- monosialoganglioside sialyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ST6GAL2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein glycosylation
- oligosaccharide metabolic process
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- beta-galactoside alpha-2,6-sialyltransferase activity