SLC7A1
SLC7A1 Gene Summary
Enables L-arginine transmembrane transporter activity and L-histidine transmembrane transporter activity. Involved in amino acid transport. Located in membrane. Part of apical plasma membrane; basolateral plasma membrane; and protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLC7A1 |
| Official Name | solute carrier family 7 member 1 [Source:HGNC Symbol;Acc:HGNC:11057] |
| Ensembl ID | ENSG00000139514 |
| Bio databases IDs | |
| Aliases | solute carrier family 7 member 1, ecotropic retroviral receptor, amino acid transporter, cationic 1 |
| Synonyms | 4831426K01RIK,ATRC1,CAT-1,EcoR,ER,ERR,HCAT1,LOC102724249,mCAT-1,Rec-1,REC1L,Rev-1,solute carrier family 7 (cationic amino acid transporter, y+ system), member 1,solute carrier family 7 member 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- viral receptor
- L-amino acid transporter
- basic amino acid transporter
- protein binding
- histidine transporter
- cationic amino acid transport permease
- organic cation transporter
- amino acid permease (GABA permease)
- lysine transporter
- amino acid permease
- ornithine transporter
- L-type amino acid transporter
- C-terminus of AA_permease
- amino acid transporter
- transporter
Pathways
Biological processes and signaling networks where the SLC7A1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- FCER1G
- SLC39A2
- HNRNPL
- RPA2
- AGPAT3
- ZRANB1
- STX7
- GOLM1
- CKAP4
- MTCH2
disease
- hypertension
- prostate cancer
- uterine leiomyoma
- leiomyomatosis
- breast carcinoma
- aldosterone producing adrenocortical adenoma
- adenoma formation
- cardiovascular disorder
- major depression
- anemia
regulated by
- HGF
- insulin
- CEBPB
- TNF
- mir-122 (includes others)
- FOXO3
- bexarotene
- D-glucose
- cisplatin
- ELAVL1
regulates
- nitric oxide
- reporter mRNA
- L-lysine
- L-ornithine
- Mir122a/b
- L-arginine
- SLC7A1
- arginine
- basic amino acid
- amino acids
role in cell
- differentiation
- proliferation
- migration
- invasion by
- number
- cell viability
- colony formation by
- abnormal morphology
- function
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- granules
- apical membrane
- basolateral membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the SLC7A1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- viral entry into host cell
- lysine transport
- L-amino acid transport
- positive regulation of T cell proliferation
- amino acid transport
- ornithine transport
CELLULAR COMPONENT
Where in the cell the gene product is active
- basal plasma membrane
- membrane
- macromolecular complex
- basolateral plasma membrane
- plasma membrane
- apical plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- L-lysine transmembrane transporter activity
- L-ornithine transmembrane transporter activity
- L-histidine transmembrane transporter activity
- basic amino acid transmembrane transporter activity
- amino acid transmembrane transporter activity
- viral receptor activity