TMEM237 Gene Summary [Human]
The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects in this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | TMEM237 |
| Official Name | transmembrane protein 237 [Source:HGNC Symbol;Acc:HGNC:14432] |
| Ensembl ID | ENSG00000155755 |
| Bio databases IDs | |
| Aliases | transmembrane protein 237 |
| Synonyms | AI853305, ALS2CR4, Gm972, JBTS14, transmembrane protein 237 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMEM237 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transmembrane protein 237
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- microtubule cytoskeleton
- ciliary transition zone
- cilia
- cellular membrane
- Plasma Membrane
- connecting cilia
- nuclear speckles
- photoreceptor outer segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMEM237 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- membrane
- ciliary transition zone
Molecular Function
What the gene product does at the molecular level
- protein binding