PLA1A Gene Summary [Human]
The protein encoded by this gene is a phospholipase that hydrolyzes fatty acids at the sn-1 position of phosphatidylserine and 1-acyl-2-lysophosphatidylserine. This secreted protein hydrolyzes phosphatidylserine in liposomes. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Details
| Type | Protein Coding |
| Official Symbol | PLA1A |
| Official Name | phospholipase A1 member A [Source:HGNC Symbol;Acc:HGNC:17661] |
| Ensembl ID | ENSG00000144837 |
| Bio databases IDs | |
| Aliases | phospholipase A1 member A, phosphatidylserine-specific phospholipase A1 |
| Synonyms | PHOSPHOLIPASE A1-alpha, phospholipase A1 member A, PHOSPHOLIPASE A1-α, PS-PLA1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLA1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipase A1
- alpha/beta hydrolases
- lipase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- dermatomyositis
- autosomal dominant polycystic kidney disease
regulates
- lipid
- cholesterol
- histamine
- lysophosphatidylserine
- phosphatidylserine
- HDL
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLA1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylserine metabolic process
- lipid metabolic process
- lipid catabolic process
- phosphatidylserine acyl-chain remodeling
Cellular Component
Where in the cell the gene product is active
- extracellular space
- acrosomal membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine 1-acylhydrolase activity
- phosphatidylcholine 1-acylhydrolase activity