RAB29 Gene Summary [Human]
Enables several functions, including dynein complex binding activity; guanyl ribonucleotide binding activity; and kinesin binding activity. Involved in several processes, including positive regulation of T cell receptor signaling pathway; positive regulation of receptor recycling; and toxin transport. Located in several cellular components, including Golgi apparatus; endosome; and vacuole. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RAB29 |
| Official Name | RAB29, member RAS oncogene family [Source:HGNC Symbol;Acc:HGNC:9789] |
| Ensembl ID | ENSG00000117280 |
| Bio databases IDs | |
| Aliases | RAB29, member RAS oncogene family |
| Synonyms | RAB29, member RAS oncogene family, RAB7L, RAB7L1, RAB7Li |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAB29 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- enzyme binding
- GTPase
- enzyme
- protein binding
- kinesin binding
- Ras subfamily of RAS small GTPases
- GTP binding
- binding protein
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- non-insulin-dependent diabetes mellitus
- Parkinson disease
- essential tremor
- prostatic carcinoma
- proximal tubular toxicity
- infection by Dengue virus 2
role in cell
- activation in
- phosphorylation in
- production in
- formation
- development
- organization
- size
- activation
- assembly
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cellular membrane
- vacuole
- vesicles
- Golgi Apparatus
- Mitochondria
- cytosol
- trans Golgi network
- cis Golgi networks
- nucleoplasm
- nuclear envelope
- recycling endosomes
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAB29 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of intracellular protein transport
- Golgi organization
- T cell activation
- intracellular protein transport
- retrograde transport, endosome to Golgi
- mitochondrion organization
- positive regulation of T cell receptor signaling pathway
- ER to Golgi vesicle-mediated transport
- synapse assembly
- response to bacterium
- melanosome organization
- negative regulation of neuron projection development
- positive regulation of receptor recycling
- protein localization in membrane
- cell differentiation
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- vacuole
- plasma membrane
- trans-Golgi network
- early endosome
- cytoskeleton
- cis-Golgi network
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoplasm
- melanosome
- intracellular membrane-bounded organelle
- mitochondrion
- endomembrane system
- cytosol
- recycling endosome
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- kinesin binding
- GDP binding
- small GTPase binding
- dynein complex binding