PRKDC Gene Summary [Human]
This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | PRKDC |
| Official Name | protein kinase, DNA-activated, catalytic subunit [Source:HGNC Symbol;Acc:HGNC:9413] |
| Ensembl ID | ENSG00000253729 |
| Bio databases IDs | |
| Aliases | protein kinase, DNA-activated, catalytic subunit, DNA-dependent protein kinase catalytic subunit |
| Synonyms | DNA-DEPENDENT protein KINASE, DNAPDcs, DNAPK, DNA-PKC, DNA-PKcs, DNPK1, DOXNPH, dxnph, HYRC, HYRC1, IMD26, p350, p460, Prkdc predicted, protein kinase, DNA activated, catalytic polypeptide, protein kinase, DNA-activated, catalytic subunit, scid, slip, XRCC7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRKDC often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA-dependent protein kinase
- protein serine/threonine kinase
- protein kinase
- Phosphatidylinositol 3- and 4-kinase
- DNA-dependent protein kinase catalytic subunit, CC1/2
- enzyme binding
- transcription factor binding
- leucine zipper domain
- protein domain specific binding
- protein binding
- autophosphorylation site
- enzyme
- FATC domain
- kinase
- kinase domain
- DNA-PKcs, N-terminal
- FAT domain
- Phosphoinositide 3-kinase, catalytic domain
- Protein Kinases, catalytic domain
- DNA-PKcs, CC5
- double-stranded DNA binding
- snoRNA binding
- DNA-dependent protein kinase catalytic subunit, CC3
Pathways
Biological processes and signaling networks where the PRKDC gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- neoplasia
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- cancer
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
- dysplasia
- breast cancer metastatic to brain
role in cell
- cell death
- apoptosis
- fragmentation
- survival
- production in
- expression in
- phosphorylation in
- activation in
- proliferation
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- low-density microsomal fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- pre-ribosome
- Cytoplasm
- Plasma Membrane
- centrosome
- midbody
- cytosol
- nucleoplasm
- nucleoli
- nuclear envelope
- nuclear scaffolds
- membrane rafts
- kinetochores
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRKDC gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- positive regulation of translation
- positive regulation of lymphocyte differentiation
- T cell lineage commitment
- regulation of circadian rhythm
- double-strand break repair via nonhomologous end joining
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- positive regulation of erythrocyte differentiation
- double-strand break repair
- cellular response to insulin stimulus
- regulation of smooth muscle cell proliferation
- heart development
- chromatin remodeling
- maturation of 5.8S rRNA
- activation of innate immune response
- telomere capping
- response to gamma radiation
- regulation of epithelial cell proliferation
- germ cell programmed cell death
- mitotic cell cycle G1/S transition DNA damage checkpoint
- T cell differentiation in thymus
- small-subunit processome assembly
- T cell receptor V(D)J recombination
- immunoglobulin V(D)J recombination
- telomere maintenance
- DNA damage response, signal transduction resulting in induction of apoptosis
- brain development
- response to DNA damage stimulus
- protein destabilization
- B cell lineage commitment
- rhythmic process
- immature B cell differentiation
- somitogenesis
- pro-B cell differentiation
- negative regulation of apoptotic process
- innate immune response
- negative regulation of protein phosphorylation
- positive regulation of apoptotic process
- positive regulation of double-strand break repair via nonhomologous end joining
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- DNA-dependent protein kinase complex
- nonhomologous end joining complex
- nucleolus
- chromatin
- nucleoplasm
- transcription factor complex
- chromosome, telomeric region
- nucleus
- DNA-dependent protein kinase-DNA ligase 4 complex
- membrane
- protein-DNA complex
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- DNA-dependent protein kinase activity
- ATP binding
- protein domain specific binding
- protein binding
- RNA binding
- double-stranded DNA binding
- U3 snoRNA binding
- protein kinase activity
- histone kinase activity (H2A-S139 specific)
- protein serine/threonine kinase activity
- enzyme binding