FABP2 Gene Summary [Human]
The protein encoded by this gene is an intracellular fatty acid-binding protein that participates in the uptake, intracellular metabolism, and transport of long-chain fatty acids. The encoded protein is also involved in the modulation of cell growth and proliferation. This protein binds saturated long-chain fatty acids with high affinity, and may act as a lipid sensor to maintain energy homeostasis. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | FABP2 |
| Official Name | fatty acid binding protein 2 [Source:HGNC Symbol;Acc:HGNC:3556] |
| Ensembl ID | ENSG00000145384 |
| Bio databases IDs | |
| Aliases | fatty acid binding protein 2 |
| Synonyms | FABP, FABPI, FABPPM, fatty acid binding protein 2, fatty acid binding protein 2, intestinal, I-FABP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FABP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- long-chain fatty acid transporter
- lipocalin/cytosolic fatty acid-binding protein family
- fatty acid binding
- protein binding
- helix-turn-helix domain
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the FABP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- diabetes mellitus
- hyperinsulinism
- metabolic syndrome X
- acute graft-vs-host disease
- intra-abdominal sepsis
- pulmonary embolism
role in cell
- proliferation
- differentiation
- formation
- morphology
- formation in
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- cytosol
- apical cortex
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FABP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid transport
- fatty acid transport
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- microvillus
- cytosol
- apical cortex
Molecular Function
What the gene product does at the molecular level
- protein binding
- fatty acid binding
- long-chain fatty acid binding
- long-chain fatty acid transporter activity