Fabp2 Gene Summary [Mouse]

The protein encoded by this gene is part of the fatty acid binding protein family (FABP). FABPs are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands and participate in fatty acid uptake, transport, and metabolism. This protein functions within enterocytes, possibly to sense lipids as part of energy homeostasis. In humans polymorphisms are associated with increased fat oxidation and insulin resistance. In mice deficiency of this gene alters body weight in a gender-specific manner and causes hyperinsulinemia. [provided by RefSeq, Jan 2013]

Details

Type
Protein Coding
Official Symbol
Fabp2
Official Name
fatty acid binding protein 2, intestinal [Source:MGI Symbol;Acc:MGI:95478]
Ensembl ID
ENSMUSG00000023057
Bio databases IDs NCBI: 14079 Ensembl: ENSMUSG00000023057
Aliases fatty acid binding protein 2, intestinal
Synonyms FABP, FABPI, FABPPM, fatty acid binding protein 2, fatty acid binding protein 2, intestinal, I-FABP
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fabp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • long-chain fatty acid transporter
  • lipocalin/cytosolic fatty acid-binding protein family
  • fatty acid binding
  • protein binding
  • helix-turn-helix domain
  • Lipocalin / cytosolic fatty-acid binding protein family
  • transporter

Pathways

Biological processes and signaling networks where the Fabp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • obesity
  • diabetes mellitus
  • hyperinsulinism
  • metabolic syndrome X
  • acute graft-vs-host disease
  • intra-abdominal sepsis
  • pulmonary embolism
regulated by
  • bisphenol A
  • palmitic acid
  • EPAS1
  • insulin
  • D-glucose
  • lipopolysaccharide
  • ethanol
  • FOXO1
  • fatty acid
  • HNF4A
regulates
role in cell
  • proliferation
  • differentiation
  • formation
  • morphology
  • formation in
  • generation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • intracellular space
  • cytosol
  • apical cortex
  • microvilli

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Fabp2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • long-chain fatty acid transport
  • fatty acid transport
  • fatty acid metabolic process

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • microvillus
  • cytosol
  • apical cortex

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • fatty acid binding
  • long-chain fatty acid binding
  • long-chain fatty acid transporter activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.