AGR2 Gene Summary [Human]
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein mucin. This gene has been implicated in inflammatory bowel disease and cancer progression. [provided by RefSeq, Mar 2017]
Details
| Type | Protein Coding |
| Official Symbol | AGR2 |
| Official Name | anterior gradient 2, protein disulphide isomerase family member [Source:HGNC Symbol;Acc:HGNC:328] |
| Ensembl ID | ENSG00000106541 |
| Bio databases IDs | |
| Aliases | anterior gradient 2, protein disulphide isomerase family member, protein disulfide isomerase family A, member 17 |
| Synonyms | AG-2, Agr2h, anterior gradient 2, anterior gradient 2, protein disulphide isomerase family member, GOB-4, HAG-2, HEL-S-116, HPC8, mAG-2, PDIA17, RIFTD, XAG-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AGR2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- KDEL sequence
- Thioredoxin-like
- epidermal growth factor receptor binding
- KTEL sequence
- KSEL sequence
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein homodimerization
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- colorectal cancer
- pancreatic cancer
- neoplasia
- acute myeloid leukemia
- epithelial cancer
- epithelial neoplasia
- cancer
- colitis
- anemia
role in cell
- proliferation
- expression in
- phosphorylation in
- cell death
- differentiation
- inhibition in
- cell viability
- number
- signaling in
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Nucleus
- Endoplasmic Reticulum
- perinuclear space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AGR2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- lung goblet cell differentiation
- mucus secretion
- positive regulation of gene expression
- positive regulation of epidermal growth factor receptor signaling pathway
- digestive tract morphogenesis
- positive regulation of cell-substrate adhesion
- positive regulation of developmental growth
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- extracellular space
- endoplasmic reticulum
- extracellular region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- epidermal growth factor receptor binding
- dystroglycan binding