FASN
FASN Gene Summary
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FASN |
| Official Name | fatty acid synthase [Source:HGNC Symbol;Acc:HGNC:3594] |
| Ensembl ID | ENSG00000169710 |
| Bio databases IDs | |
| Aliases | fatty acid synthase, short chain dehydrogenase/reductase family 27X, member 1, [Acyl-carrier-protein] S-acetyltransferase, [Acyl-carrier-protein] S-malonyltransferase, 3-oxoacyl-[acyl-carrier-protein] synthase, 3-oxoacyl-[acyl-carrier-protein] reductase, 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, Enoyl-[acyl-carrier-protein] reductase, Acyl-[acyl-carrier-protein] hydrolase |
| Synonyms | A630082H08Rik,FAS,FASH,fatty acid synthase,Long chain fatty acyl-coa synthetase,NADP Dependent Oxidoreductase,nFAS,OA-519,SDR27X1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- malonyl CoA-acyl carrier protein transacylase
- Beta-ketoacyl synthase domain
- MDR
- Zinc-binding dehydrogenase
- Ketoacyl-synthetase C-terminal extension
- [acyl-carrier-protein] S-acetyltransferase
- enzyme
- Beta-ketoacyl synthase, C-terminal domain
- AdoMet_MTases
- Enoyl reductase domain
- identical protein binding
- methyltransferase domain
- polyketide synthase keto reductase domain
- 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase
- putative NAD(P)H quinone oxidoreductase, PIG3 family
- enoyl-[acyl-carrier-protein] reductase (NADPH2, A-specific)
- hot_dog
- 3-oxoacyl-[acyl-carrier-protein] reductase
- [acyl-carrier-protein] S-malonyltransferase
- 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase
- Phosphopantetheine attachment site
- Beta-ketoacyl reductase domain
- alpha/beta hydrolases
- KR domain
- central domain
- Acyl transferase domain
- protein binding
- Enoylreductase
- dehydrase domain
- cond_enzymes
- acyl carrier protein domain
- Malonyl-acetyl transferase domain
- binding protein
- Beta-ketoacyl synthase
- Thioesterase domain
- 3-oxoacyl-[acyl-carrier-protein] synthase
- crotonoyl-[acyl-carrier-protein] hydratase
- oleoyl-[acyl-carrier-protein] hydrolase
- fatty-acid synthase
Pathways
Biological processes and signaling networks where the FASN gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- FOS
- AAR2
- HAUS4
- MAP1B
- GBF1
- GRN
- BRCA1
- AR
- HSF1
- HDAC6
disease
- cancer
- neoplasia
- diabetes mellitus
- pancreatic cancer
- prostate cancer
- nonalcoholic steatohepatitis
- obesity
- liver cancer
- recurrent glioblastoma
- glioblastoma
regulated by
- lipopolysaccharide
- ethanol
- AKR1C3
- FGF21
- curcumin
- methylnitrosourea
- voacamine
- PRDX6
- hydrogen peroxide
- arsenic trioxide
regulates
- TNF
- IL6
- D-glucose
- lactic acid
- CDKN1A
- SKP2
- TP53
- AKT
- fatty acid
- CASP3
role in cell
- phosphorylation in
- activation in
- apoptosis
- cell viability
- production in
- expression in
- proliferation
- differentiation
- cell death
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- extracellular vesicles
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- growth cone
- perikaryon
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the FASN gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- mammary gland development
- inflammatory response
- cellular response to interleukin-4
- osteoblast differentiation
- fatty acid biosynthetic process
- monocyte differentiation
- neutrophil differentiation
- glandular epithelial cell development
- fatty acid metabolic process
- ether lipid biosynthetic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- melanosome
- membrane
- cytosol
- Golgi apparatus
- glycogen granule
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity
- [acyl-carrier-protein] S-acetyltransferase activity
- fatty acid synthase activity
- 3-oxoacyl-[acyl-carrier-protein] synthase activity
- 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
- crotonoyl-[acyl-carrier-protein] hydratase activity
- [acyl-carrier-protein] S-malonyltransferase activity
- 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
- (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity
- 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
- protein binding
- RNA binding
- cadherin binding
- acyl-[acyl-carrier-protein] hydrolase activity
- phosphopantetheine binding