Fabp2 Gene Summary [Rat]
Enables long-chain fatty acid binding activity and long-chain fatty acid transmembrane transporter activity. Involved in fatty acid metabolic process; intestinal absorption; and long-chain fatty acid transport. Located in apical cortex and microvillus. Human ortholog(s) of this gene implicated in alcoholic liver cirrhosis; carotid stenosis; coronary artery disease; end stage renal disease; and obesity. Orthologous to human FABP2 (fatty acid binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fabp2 |
| Official Name | fatty acid binding protein 2 [Source:RGD Symbol;Acc:2591] |
| Ensembl ID | ENSRNOG00000024947 |
| Bio databases IDs | |
| Aliases | fatty acid binding protein 2 |
| Synonyms | FABP, FABPI, FABPPM, fatty acid binding protein 2, fatty acid binding protein 2, intestinal, I-FABP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fabp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- long-chain fatty acid transporter
- lipocalin/cytosolic fatty acid-binding protein family
- fatty acid binding
- protein binding
- helix-turn-helix domain
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the Fabp2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- diabetes mellitus
- hyperinsulinism
- metabolic syndrome X
- acute graft-vs-host disease
- intra-abdominal sepsis
- pulmonary embolism
role in cell
- proliferation
- differentiation
- formation
- morphology
- formation in
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- cytosol
- apical cortex
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fabp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- long-chain fatty acid transport
- fatty acid transport
- fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- microvillus
- cytosol
- apical cortex
Molecular Function
What the gene product does at the molecular level
- protein binding
- fatty acid binding
- long-chain fatty acid binding
- long-chain fatty acid transporter activity