TBK1 Gene Summary [Human]
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021]
Details
| Type | Retained Intron |
| Official Symbol | TBK1 |
| Official Name | TANK binding kinase 1 [Source:HGNC Symbol;Acc:HGNC:11584] |
| Ensembl ID | ENSG00000183735 |
| Bio databases IDs | |
| Aliases | TANK binding kinase 1 |
| Synonyms | 1200008B05Rik, AIARV, FTDALS4, IIAE8, LOC299827, NAK, T2K, TANK-binding kinase 1, Tbk |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TBK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TANK-binding kinase 1 coiled-coil domain 1
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- nucleic acid binding
- protein phosphatase binding
- phosphoprotein binding
- transcription factor binding
- coiled-coil domain
- protein binding
- ubiquitin-like domain
- identical protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- TBK1_IKKE-like_C
- kinase domain
- Protein Kinases, catalytic domain
- Ubl1_cv_Nsp3_N-like
- TANK binding kinase 1 ubiquitin-like domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the TBK1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- insulin resistance
- frontotemporal dementia and/or amyotrophic lateral sclerosis 4
- motor neuron disease
- TBK1 related disease
- colorectal cancer
- frontotemporal dementia with parkinsonism
- amyotrophic lateral sclerosis
- organismal death
role in cell
- proliferation
- cell death
- survival
- production in
- expression in
- migration
- apoptosis
- activation in
- cell viability
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Mitochondria
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TBK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of type I interferon-mediated signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- protein phosphorylation
- response to virus
- positive regulation of transcription from RNA polymerase II promoter
- cytoplasmic pattern recognition receptor signaling pathway
- positive regulation of interferon-alpha production
- inflammatory response
- activation of innate immune response
- positive regulation of interferon-beta production
- defense response to virus
- defense response to Gram-positive bacterium
- positive regulation of peptidyl-serine phosphorylation
- positive regulation of macroautophagy
- positive regulation of type I interferon production
- toll-like receptor 4 signaling pathway
- dendritic cell proliferation
- I-kappaB kinase/NF-kappaB cascade
- type I interferon-mediated signaling pathway
- positive regulation of autophagy
- negative regulation of gene expression
- innate immune response
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
- regulation of type I interferon production
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- ATP binding
- identical protein binding
- protein binding
- protein phosphatase binding
- protein kinase activity
- phosphoprotein binding
- protein serine/threonine kinase activity