Trim7 Gene Summary [Mouse]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in antiviral innate immune response. Located in cytoplasm and nucleus. Orthologous to human TRIM7 (tripartite motif containing 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim7 |
| Official Name | tripartite motif-containing 7 [Source:MGI Symbol;Acc:MGI:2137353] |
| Ensembl ID | ENSMUSG00000040350 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 7 |
| Synonyms | AL645849.2, GNIP, RNF90, tripartite motif-containing 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- Ring finger domain
- protein binding
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- Ring finger
- B-box zinc finger
- Apolipoprotein A1/A4/E domain
- SPRY-associated domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- monoclonal gammopathy of undertermined significance
- glioma formation
- carcinoma
- breast cancer
- ischemic cardiomyopathy
- asthma
- Alzheimer disease
- glioblastoma
- glioblastoma cancer
regulated by
- doxorubicin
- ETV6-RUNX1
- A549 cells
- METTL3
- THP-1 cells
regulates
- 2Bc
- POLY
- glycogenin
role in cell
- degradation in
- inhibition in
- innate immune response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding