CCT6A Gene Summary [Human]
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | CCT6A |
| Official Name | chaperonin containing TCP1 subunit 6A [Source:HGNC Symbol;Acc:HGNC:1620] |
| Ensembl ID | ENSG00000146731 |
| Bio databases IDs | |
| Aliases | chaperonin containing TCP1 subunit 6A |
| Synonyms | CCT6, Cctz, Cctz-1, CCT-zeta, CCT-zeta-1, CCT-ζ, CCT-ζ-1, Chaperonin 6a, chaperonin containing TCP1 subunit 6A, HTR3, LOC100038887, MoDP-2, TCP-1-zeta, TCP-1-ζ, TCP20, TCPZ, TTCP20 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCT6A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- T-complex protein 1, beta subunit
- T-complex protein 1, alpha subunit
- T-complex protein 1, zeta subunit
- thermosome, various subunits, archaeal
- T-complex protein 1, eta subunit
- T-complex protein 1, delta subunit
- T-complex protein 1, gamma subunit
- protein domain specific binding
- protein binding
- chaperonin_like
- TCP-1/cpn60 chaperonin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- overall survival
- coronary artery disease
role in cell
- survival
- cell death
- proliferation
- apoptosis
- invasion by
- sphere formation by
- expression in
- disruption in
- aggregation in
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- Nucleus
- microtubules
- cytosol
- acrosome
- perikaryon
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCT6A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone-mediated protein folding
- positive regulation of telomere maintenance via telomerase
- protein folding
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- chaperonin-containing T-complex
- extracellular vesicular exosome
- cytoplasm
- cytosol
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- protein binding
- protein binding involved in protein folding
- unfolded protein binding
- WD40-repeat domain binding