NTMT1 Gene Summary [Human]
The METTL11A gene encodes an N-terminal methyltransferase for the RAN (MIM 601179) guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1; MIM 179710). METTL11A enzyme alpha-N-methylates other protein targets such as SET (MIM 600960) and RB (MIM 180200).[supplied by OMIM, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | NTMT1 |
| Official Name | N-terminal Xaa-Pro-Lys N-methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:23373] |
| Ensembl ID | ENSG00000148335 |
| Bio databases IDs | |
| Aliases | N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
| Synonyms | 2610205E22Rik, AD-003, C9orf32, HOMT1A, METTL11A, NRMT, NRMT1, N-terminal Xaa-Pro-Lys N-methyltransferase 1, NTM1A, RGD1306582 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NTMT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein methyltransferase
- histone methyltransferase
- enzyme
- AdoMet_MTases
- protein binding
- methyltransferase domain
- S-adenosylmethionine-dependent methyltransferase
- AdoMet dependent proline di-methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- prostate cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- head and neck squamous cell carcinoma
role in cell
- apoptosis
- proliferation
- organization
- damage in
- segregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NTMT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- N-terminal peptidyl-serine dimethylation
- spindle organization
- N-terminal peptidyl-serine trimethylation
- chromatin remodeling
- N-terminal peptidyl-serine methylation
- N-terminal peptidyl-alanine methylation
- N-terminal peptidyl-glycine methylation
- chromosome segregation
- N-terminal peptidyl-proline dimethylation
- N-terminal peptidyl-proline methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein methyltransferase activity
- histone methyltransferase activity
- N-terminal protein N-methyltransferase activity