DIS3 Gene Summary [Human]
Enables 3'-5'-exoribonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DIS3 |
| Official Name | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [Source:HGNC Symbol;Acc:HGNC:20604] |
| Ensembl ID | ENSG00000083520 |
| Bio databases IDs | |
| Aliases | DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease, exosome component 11 |
| Synonyms | 2810028N01Rik, DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease, dis3p, EXOSC11, KIAA1008, RGD1304646, RRP44 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DIS3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cold shock domain
- Dis3-like cold-shock domain 2 (CSD2)
- Rrp44-like cold shock domain
- VacB and RNase II family 3'-5' exoribonucleases
- enzyme
- protein binding
- This domain is the catalytic domain of ribonuclease II
- 3'-5' exoribonuclease
- endonuclease
- ribonuclease R
- S1 domain
- PIN domain
- RNB domain
- guanyl-nucleotide exchange factor
- Large family of predicted nucleotide-binding domains
- PIN (PilT N terminus) domain: Superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DIS3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear mRNA surveillance of mRNA 3'-end processing
- CUT catabolic process
- rRNA catabolic process
- RNA processing
- rRNA processing
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasmic exosome (RNase complex)
- nuclear exosome (RNase complex)
- nucleus
- membrane
- cytosol
- nucleolus
- exosome (RNase complex)
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- 3'-5'-exoribonuclease activity
- RNA binding
- protein binding
- endonuclease activity
- guanyl-nucleotide exchange factor activity