DRG1 Gene Summary [Human]
Enables several functions, including GTPase activity; identical protein binding activity; and potassium ion binding activity. Involved in positive regulation of microtubule polymerization and regulation of mitotic spindle assembly. Located in cytosol and nuclear body. Part of polysome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DRG1 |
| Official Name | developmentally regulated GTP binding protein 1 [Source:HGNC Symbol;Acc:HGNC:3029] |
| Ensembl ID | ENSG00000185721 |
| Bio databases IDs | |
| Aliases | developmentally regulated GTP binding protein 1 |
| Synonyms | developmentally regulated GTP binding protein 1, NEDD-3, TANALS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DRG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- TGS domain
- small GTP-binding protein domain
- Ubl1_cv_Nsp3_N-like
- 50S ribosome-binding GTPase
- GTPase
- metal ion binding
- enzyme
- protein binding
- C-terminal region of MMR_HSR1 domain
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Tan-Almurshedi syndrome
- colon cancer
- colorectal cancer
- age-related hearing loss
- Dukes stage C colorectal cancer
role in cell
- assembly
- docetaxel resistance
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- polyribosome fractions
- Nucleus
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DRG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- positive regulation of microtubule polymerization
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- identical protein binding
- protein binding
- potassium ion binding
- GTPase activity
- microtubule binding