SESN3 Gene Summary [Human]
This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Details
| Type | Protein Coding |
| Official Symbol | SESN3 |
| Official Name | sestrin 3 [Source:HGNC Symbol;Acc:HGNC:23060] |
| Ensembl ID | ENSG00000149212 |
| Bio databases IDs | |
| Aliases | sestrin 3 |
| Synonyms | 5630400E15Rik, SEST3, SESTRIN 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SESN3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PA26 p53-induced protein (sestrin)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sarcoidosis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
regulates
- reactive oxygen species
- MTORC1
- D-glucose
role in cell
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SESN3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- regulation of protein kinase B signaling cascade
- response to insulin stimulus
- cellular response to leucine
- cellular response to amino acid starvation
- glucose homeostasis
- regulation of insulin receptor signaling pathway
- cellular response to glucose starvation
Cellular Component
Where in the cell the gene product is active
- nucleus
- TORC2 complex
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- leucine binding
- protein binding
- oxidoreductase activity, acting on peroxide as acceptor