Sesn3 Gene Summary [Mouse]
Predicted to enable L-leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in several processes, including TORC2 signaling; regulation of signal transduction; and response to insulin. Acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Part of TORC2 complex. Is expressed in brain; cortical plate; and embryo. Orthologous to human SESN3 (sestrin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sesn3 |
| Official Name | sestrin 3 [Source:MGI Symbol;Acc:MGI:1922997] |
| Ensembl ID | ENSMUSG00000032009 |
| Bio databases IDs | |
| Aliases | sestrin 3 |
| Synonyms | 5630400E15Rik, SEST3, SESTRIN 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sesn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PA26 p53-induced protein (sestrin)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sarcoidosis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
regulates
- reactive oxygen species
- MTORC1
- D-glucose
role in cell
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sesn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- regulation of protein kinase B signaling cascade
- response to insulin stimulus
- cellular response to leucine
- cellular response to amino acid starvation
- glucose homeostasis
- regulation of insulin receptor signaling pathway
- cellular response to glucose starvation
Cellular Component
Where in the cell the gene product is active
- nucleus
- TORC2 complex
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- leucine binding
- protein binding
- oxidoreductase activity, acting on peroxide as acceptor