IRF2BP1 Gene Summary [Human]
Enables transcription corepressor activity and ubiquitin protein ligase activity. Involved in protein polyubiquitination. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | IRF2BP1 |
| Official Name | interferon regulatory factor 2 binding protein 1 [Source:HGNC Symbol;Acc:HGNC:21728] |
| Ensembl ID | ENSG00000170604 |
| Bio databases IDs | |
| Aliases | interferon regulatory factor 2 binding protein 1 |
| Synonyms | 6330414O09Rik, C530033F24, interferon regulatory factor 2 binding protein 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IRF2BP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ring like zinc finger domain
- transcription regulator
- ubiquitin protein ligase activity
- transcription co-repressor
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- transcription factor binding
- protein binding
- Interferon regulatory factor 2-binding protein zinc finger
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IRF2BP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- protein polyubiquitination
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- transcription corepressor activity