MS4A3 Gene Summary [Human]

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
MS4A3
Official Name
membrane spanning 4-domains A3 [Source:HGNC Symbol;Acc:HGNC:7317]
Ensembl ID
ENSG00000149516
Bio databases IDs NCBI: 932 Ensembl: ENSG00000149516
Aliases membrane spanning 4-domains A3
Synonyms AC226593.1, CD20L, HTM4, membrane spanning 4-domains A3
Species
Human, Homo sapiens
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MS4A3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein binding
  • CD20-like family

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • septic shock
regulated by
  • dexamethasone
  • tretinoin
  • corticosteroid
  • DNMT1
  • filgrastim
  • interferon alfacon-1
  • LY-2510924
  • TGME49_240060
  • TGM2
  • SLC38A4-AS1
regulates
role in cell
  • phosphorylation in
  • endocytosis in
  • G0/G1 phase transition

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • microsomal fraction
  • intracellular space
  • perinuclear region
  • cellular membrane
  • Nucleus
  • Plasma Membrane
  • specific granule membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human MS4A3 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • perinuclear region of cytoplasm
  • plasma membrane
  • specific granule membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.