EFNA5 Gene Summary [Human]
Ephrin-A5, a member of the ephrin gene family, prevents axon bundling in cocultures of cortical neurons with astrocytes, a model of late stage nervous system development and differentiation. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | EFNA5 |
| Official Name | ephrin A5 [Source:HGNC Symbol;Acc:HGNC:3225] |
| Ensembl ID | ENSG00000184349 |
| Bio databases IDs | |
| Aliases | ephrin A5, EPH-related receptor tyrosine kinase ligand 7 |
| Synonyms | AF1, AL-1, AV158822, EFL-5, Ephrin-A5, Epl7, EPLG7, GLC1M, LERK-7, RAGS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EFNA5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Ephrin
- Cupredoxin superfamily
- chemorepellant
- ephrin receptor binding
- protein binding
- neurotrophin TRKB receptor binding
- hydrophobic domain
Pathways
Biological processes and signaling networks where the EFNA5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- gestational diabetes mellitus
- idiopathic pulmonary fibrosis
- insomnia
- schizophrenia
- epithelial cancer
- Alzheimer disease
- post-traumatic stress disorder
- bleeding
- hippocampal atrophy
role in cell
- proliferation
- cell viability
- expression in
- phosphorylation in
- binding in
- survival
- signaling in
- migration
- cell rounding
- collapse
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble fractions
- detergent resistant lipid raft fraction
- dendrite tip
- cell surface
- cell periphery
- cellular membrane
- plasma membrane extracellular face
- synapse
- perikaryon
- cell-cell adherens junctions
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EFNA5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of insulin secretion involved in cellular response to glucose stimulus
- negative chemotaxis
- retinal ganglion cell axon guidance
- regulation of microtubule cytoskeleton organization
- regulation of cell morphogenesis
- regulation of cell-cell adhesion
- negative regulation of substrate adhesion-dependent cell spreading
- nervous system development
- axon guidance
- collateral sprouting
- cellular response to follicle-stimulating hormone stimulus
- positive regulation of collateral sprouting
- regulation of focal adhesion assembly
- regulation of actin cytoskeleton organization
- regulation of GTPase activity
- positive regulation of protein phosphorylation
- ephrin receptor signaling pathway
- apoptotic process
- positive regulation of synapse assembly
- positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- caveola
- basement membrane
- adherens junction
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neurotrophin TRKC receptor binding
- protein binding
- ephrin receptor binding
- transmembrane receptor protein tyrosine kinase activator activity
- chemorepellent activity
- neurotrophin TRKB receptor binding
- neurotrophin TRKA receptor binding