IFITM3 Gene Summary [Human]
Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]
Details
| Type | Processed Transcript |
| Official Symbol | IFITM3 |
| Official Name | interferon induced transmembrane protein 3 [Source:HGNC Symbol;Acc:HGNC:5414] |
| Ensembl ID | ENSG00000142089 |
| Bio databases IDs | |
| Aliases | interferon induced transmembrane protein 3, dispanin subfamily A member 2b |
| Synonyms | 1-8U, DSPA2b, FGLS, IFN1-8U, interferon induced transmembrane protein 3, IP15 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFITM3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Interferon-induced transmembrane protein
- protein binding
Pathways
Biological processes and signaling networks where the IFITM3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- neoplasia
- multiple sclerosis
- infection
- COVID-19
- organismal death
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- diabetic nephropathy
- schizophrenia
- disease-free survival
role in cell
- growth
- phosphorylation in
- production in
- expression in
- migration
- invasion by
- accumulation in
- replication in
- proliferation
- fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- lysosome
- lysosome membrane
- endosomal membrane
- early endosomes
- late endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFITM3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- negative regulation of viral entry into host cell
- response to interferon-gamma
- defense response to virus
- response to virus
- response to interferon-alpha
- negative regulation of viral genome replication
- response to interferon-beta
- negative regulation of viral transcription
- type I interferon-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- late endosome membrane
- perinuclear region of cytoplasm
- macromolecular complex
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding