KLRF1 Gene Summary [Human]
KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | KLRF1 |
| Official Name | killer cell lectin like receptor F1 [Source:HGNC Symbol;Acc:HGNC:13342] |
| Ensembl ID | ENSG00000150045 |
| Bio databases IDs | |
| Aliases | killer cell lectin like receptor F1 |
| Synonyms | CLEC5C, killer cell lectin like receptor F1, NKP80 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLRF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- ectodomain
- Lectin C-type domain
- transmembrane receptor
- MHC class I receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- sepsis
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- idiopathic pulmonary fibrosis
- severe preeclampsia
role in cell
- activation
- cytotoxicity
- priming
- degranulation
- tyrosine phosphorylation in
- cytotoxic reaction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLRF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- NK T cell activation
- cell surface receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- MHC class I receptor activity
- carbohydrate binding