SCLT1 Gene Summary [Human]
This gene encodes an adaptor protein. Studies of a related gene in rat suggest that the encoded protein functions to link clathrin to the sodium channel protein type 10 subunit alpha protein. The encoded protein has also been identified as a component of distal appendages of centrioles that is necessary for ciliogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Processed Transcript |
| Official Symbol | SCLT1 |
| Official Name | sodium channel and clathrin linker 1 [Source:HGNC Symbol;Acc:HGNC:26406] |
| Ensembl ID | ENSG00000151466 |
| Bio databases IDs | |
| Aliases | sodium channel and clathrin linker 1 |
| Synonyms | 2610207F23Rik, 4931421F20Rik, CAGGS-SB10, CAP-1A, Sap1, sodium channel and clathrin linker 1, Tg(ACTB-sb10)1Dla, Tg(CAG-sb10)1Dla |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SCLT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Centrosomal colon cancer autoantigen protein family
- clathrin binding
- sodium channel regulator
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- Bardet-Biedl syndrome
role in cell
- phosphorylation in
- disruption
- assembly
- cell spreading
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microtubule cytoskeleton
- ciliary transition fiber
- basal bodies
- centrosome
- centriole
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SCLT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clustering of voltage-gated sodium channels
- cilium morphogenesis
Cellular Component
Where in the cell the gene product is active
- centrosome
- centriole
- cytosol
- clathrin complex
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- clathrin binding