PCM1 Gene Summary [Human]
The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | PCM1 |
| Official Name | pericentriolar material 1 [Source:HGNC Symbol;Acc:HGNC:8727] |
| Ensembl ID | ENSG00000078674 |
| Bio databases IDs | |
| Aliases | pericentriolar material 1 |
| Synonyms | 2600002H09Rik, 9430077F19Rik, C030044G17Rik, LOC100044052, pericentriolar material 1, PTC4, RET/PCM-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PCM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- matrix binding domain
- Pericentriolar material 1 C terminus
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- cleft palate
- breast carcinoma
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- atrial fibrillation
- polycystic ovary syndrome
role in cell
- migration
- cell cycle progression
- assembly
- senescence
- cycling
- formation
- interaction in
- mitosis
- replication
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- ciliary transition zone
- pericentriolar matrix
- heterochromatin
- centriolar satellite
- cilia
- apical compartment
- basal bodies
- centrosome
- centriole
- granules
- cytosol
- nuclear foci
- nucleoplasm
- nuclear envelope
- photoreceptor inner segments
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PCM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- positive regulation of intracellular protein transport
- cilium morphogenesis
- centrosome cycle
- microtubule anchoring
- neuronal stem cell maintenance
- interkinetic nuclear migration
- neuron migration
- intraflagellar transport involved in cilium morphogenesis
- negative regulation of neurogenesis
- cytoplasmic microtubule organization
- microtubule anchoring at centrosome
- protein localization to centrosome
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- centriolar satellite
- nucleoplasm
- pericentriolar material
- centrosome
- nuclear membrane
- apical part of cell
- centriole
- cytoplasm
- membrane
- cytosol
- macromolecular complex
- ciliary transition zone
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- binding, bridging