SPEF2 Gene Summary [Human]
Involved in sperm axoneme assembly. Located in sperm flagellum. Implicated in spermatogenic failure 43. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SPEF2 |
| Official Name | sperm flagellar 2 [Source:HGNC Symbol;Acc:HGNC:26293] |
| Ensembl ID | ENSG00000152582 |
| Bio databases IDs | |
| Aliases | sperm flagellar 2, cancer/testis antigen 122 |
| Synonyms | C230086A09Rik, CT122, KPL2, LOC100912019, sperm flagellar 2, SPGF43 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPEF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CH-like domain in sperm protein
- zinc finger in transposases and transcription factors
- NK
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cilia
- manchette
- Golgi Apparatus
- cytosol
- nuclear bodies
- sperm midpiece
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPEF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- respiratory system development
- spermatogenesis
- epithelial cilium movement
- brain morphogenesis
- sperm axoneme assembly
- skeletal system morphogenesis
Cellular Component
Where in the cell the gene product is active
- sperm midpiece
- cytoplasm
- Golgi apparatus
- extracellular region
- sperm flagellum
- manchette