Spef2

Predicted to enable protein dimerization activity. Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within several processes, including brain morphogenesis; epithelial cilium movement involved in extracellular fluid movement; and sperm flagellum assembly. Predicted to be located in several cellular components, including Golgi apparatus; nuclear body; and sperm flagellum. Predicted to be active in manchette and sperm midpiece. Human ortholog(s) of this gene implicated in spermatogenic failure 43. Orthologous to human SPEF2 (sperm flagellar 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spef2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Spef2 gene, providing context for its role in the cell.