GGPS1 Gene Summary [Human]
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Details
| Type | Protein Coding |
| Official Symbol | GGPS1 |
| Official Name | geranylgeranyl diphosphate synthase 1 [Source:HGNC Symbol;Acc:HGNC:4249] |
| Ensembl ID | ENSG00000152904 |
| Bio databases IDs | |
| Aliases | geranylgeranyl diphosphate synthase 1, Geranylgeranyl pyrophosphate synthase |
| Synonyms | 1810026C22Rik, 9530089B04Rik, Crlf3, geranylgeranyl diphosphate synthase 1, GGPPS, GGPPS1, GGPP synthetase, Gpp synthase, MDHLO, MUDHLOV, rGGPS1a, rGGPS1a1, rGGPS1a2, rGGPS1a3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GGPS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- geranyltranstransferase
- Isoprenoid Biosynthesis enzymes, Class 1
- dimethylallyltranstransferase
- Polyprenyl synthetase
- enzyme
- protein binding
- identical protein binding
- farnesyltranstransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic breast cancer
- locally advanced breast cancer
- HIV infection
- breast cancer
- metastasis
- pain
- multiple sclerosis
- neoplasia
- hip osteoarthritis
- diabetes mellitus
role in cell
- growth
- signaling in
- activation in
- tyrosine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GGPS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- geranylgeranyl diphosphate biosynthetic process
- geranyl diphosphate biosynthetic process
- isoprenoid biosynthetic process
- farnesyl diphosphate biosynthetic process
- isoprenoid metabolic process
Cellular Component
Where in the cell the gene product is active
- Z disc
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- geranyltranstransferase activity
- identical protein binding
- protein binding
- metal ion binding
- prenyltransferase activity
- dimethylallyltranstransferase activity
- farnesyltranstransferase activity