IKZF5 Gene Summary [Human]
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
Details
| Type | Protein Coding |
| Official Symbol | IKZF5 |
| Official Name | IKAROS family zinc finger 5 [Source:HGNC Symbol;Acc:HGNC:14283] |
| Ensembl ID | ENSG00000095574 |
| Bio databases IDs | |
| Aliases | IKAROS family zinc finger 5 |
| Synonyms | 2610034F18Rik, IKAROS family zinc finger 5, PEGASUS, THC7, Zfpn1a5, ZNFN1A5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IKZF5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- zinc ion binding
- double-stranded DNA binding
- nucleic acid binding
- Zinc-finger double domain
- protein domain specific binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IKZF5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- sequence-specific DNA binding transcription factor activity
- zinc ion binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- chromatin binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription