Ggps1 Gene Summary [Rat]
Predicted to enable (2E,6E)-farnesyl diphosphate synthase activity; geranylgeranyl diphosphate synthase activity; and identical protein binding activity. Predicted to be involved in isoprenoid biosynthetic process. Predicted to be located in several cellular components, including Z disc; nucleoplasm; and perinuclear region of cytoplasm. Orthologous to human GGPS1 (geranylgeranyl diphosphate synthase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ggps1 |
| Official Name | geranylgeranyl diphosphate synthase 1 [Source:RGD Symbol;Acc:1359680] |
| Ensembl ID | ENSRNOG00000016767 |
| Bio databases IDs | |
| Aliases | geranylgeranyl diphosphate synthase 1 |
| Synonyms | 1810026C22Rik, 9530089B04Rik, Crlf3, geranylgeranyl diphosphate synthase 1, GGPPS, GGPPS1, GGPP synthetase, Gpp synthase, MDHLO, MUDHLOV, rGGPS1a, rGGPS1a1, rGGPS1a2, rGGPS1a3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ggps1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- geranyltranstransferase
- Isoprenoid Biosynthesis enzymes, Class 1
- dimethylallyltranstransferase
- Polyprenyl synthetase
- enzyme
- protein binding
- identical protein binding
- farnesyltranstransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic breast cancer
- locally advanced breast cancer
- HIV infection
- breast cancer
- metastasis
- pain
- multiple sclerosis
- neoplasia
- hip osteoarthritis
- diabetes mellitus
role in cell
- growth
- signaling in
- activation in
- tyrosine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cytosol
- nucleoplasm
- Z line
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ggps1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- geranylgeranyl diphosphate biosynthetic process
- geranyl diphosphate biosynthetic process
- isoprenoid biosynthetic process
- farnesyl diphosphate biosynthetic process
- isoprenoid metabolic process
Cellular Component
Where in the cell the gene product is active
- Z disc
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- geranyltranstransferase activity
- identical protein binding
- protein binding
- metal ion binding
- prenyltransferase activity
- dimethylallyltranstransferase activity
- farnesyltranstransferase activity