SDHAF4 Gene Summary [Human]
Predicted to enable enzyme activator activity. Involved in cellular respiration and mitochondrial respiratory chain complex II assembly. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | SDHAF4 |
| Official Name | succinate dehydrogenase complex assembly factor 4 [Source:HGNC Symbol;Acc:HGNC:20957] |
| Ensembl ID | ENSG00000154079 |
| Bio databases IDs | |
| Aliases | succinate dehydrogenase complex assembly factor 4 |
| Synonyms | 1110058L19Rik, 1700001E18Rik, C6orf57, LOC684207, Sdh8, succinate dehydrogenase complex assembly factor 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SDHAF4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF1674)
- enzyme
- protein binding
- enzyme activator activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SDHAF4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- cellular respiration
- mitochondrial respiratory chain complex II assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme activator activity