Sdhaf4 Gene Summary [Mouse]
Enables enzyme activator activity. Involved in cellular respiration; mitochondrial respiratory chain complex II assembly; and positive regulation of succinate dehydrogenase activity. Acts upstream of or within innate immune response. Located in mitochondrion. Used to study dilated cardiomyopathy. Orthologous to human SDHAF4 (succinate dehydrogenase complex assembly factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sdhaf4 |
| Official Name | succinate dehydrogenase complex assembly factor 4 [Source:MGI Symbol;Acc:MGI:1915252] |
| Ensembl ID | ENSMUSG00000026154 |
| Bio databases IDs | |
| Aliases | succinate dehydrogenase complex assembly factor 4 |
| Synonyms | 1110058L19Rik, 1700001E18Rik, C6orf57, LOC684207, Sdh8, succinate dehydrogenase complex assembly factor 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sdhaf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF1674)
- enzyme
- protein binding
- enzyme activator activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sdhaf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- cellular respiration
- mitochondrial respiratory chain complex II assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme activator activity