MMP21 Gene Summary [Human]

This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]

Details

Type
Nonsense Mediated Decay
Official Symbol
MMP21
Official Name
matrix metallopeptidase 21 [Source:HGNC Symbol;Acc:HGNC:14357]
Ensembl ID
ENSG00000154485
Bio databases IDs NCBI: 118856 Ensembl: ENSG00000154485
Aliases matrix metallopeptidase 21
Synonyms b2b2458Clo, b2b873Clo, HTX7, matrix metallopeptidase 21
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MMP21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Putative peptidoglycan binding domain
  • metallopeptidase
  • Hemopexin-like repeats
  • Matrixin
  • ZnMc
  • peptidase
  • HX
  • Zinc-dependent metalloprotease

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • neoplasia
  • autosomal visceral heterotaxy-7
  • situs ambiguus
  • congenital heart disease
  • Dupuytren contracture
  • lung cancer
  • breast cancer
  • osteoarthritis
regulated by
  • TNF
  • interferon alpha
  • marimastat
role in cell
  • differentiation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human MMP21 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • determination of heart left/right asymmetry
  • proteolysis
  • extracellular matrix organization
  • coronary vasculature development
  • collagen catabolic process
  • hemopoietic progenitor cell differentiation
  • determination of left/right symmetry

Cellular Component

Where in the cell the gene product is active
  • extracellular matrix
  • extracellular region

Molecular Function

What the gene product does at the molecular level
  • zinc ion binding
  • metalloendopeptidase activity

Gene-Specific Assays for Results You Can Trust

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