Mmp21 Gene Summary [Rat]
Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process; determination of heart left/right asymmetry; and extracellular matrix organization. Predicted to act upstream of or within coronary vasculature development; determination of left/right symmetry; and hematopoietic progenitor cell differentiation. Predicted to be located in extracellular matrix. Human ortholog(s) of this gene implicated in visceral heterotaxy 7. Orthologous to human MMP21 (matrix metallopeptidase 21). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mmp21 |
| Official Name | matrix metallopeptidase 21 [Source:RGD Symbol;Acc:1309332] |
| Ensembl ID | ENSRNOG00000017756 |
| Bio databases IDs | |
| Aliases | matrix metallopeptidase 21 |
| Synonyms | b2b2458Clo, b2b873Clo, HTX7, matrix metallopeptidase 21 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mmp21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative peptidoglycan binding domain
- metallopeptidase
- Hemopexin-like repeats
- Matrixin
- ZnMc
- peptidase
- HX
- Zinc-dependent metalloprotease
Pathways
Biological processes and signaling networks where the Mmp21 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Axonal Guidance Signaling
- Bladder Cancer Signaling
- Colorectal Cancer Metastasis Signaling
- Estrogen Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- HIF1α Signaling
- Inhibition of Matrix Metalloproteases
- Leukocyte Extravasation Signaling
- Molecular Mechanisms of Cancer
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mmp21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- determination of heart left/right asymmetry
- proteolysis
- extracellular matrix organization
- coronary vasculature development
- collagen catabolic process
- hemopoietic progenitor cell differentiation
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- metalloendopeptidase activity