CNOT8 Gene Summary [Human]
Enables poly(A)-specific ribonuclease activity. Involved in exonucleolytic catabolism of deadenylated mRNA and positive regulation of cell population proliferation. Located in nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | CNOT8 |
| Official Name | CCR4-NOT transcription complex subunit 8 [Source:HGNC Symbol;Acc:HGNC:9207] |
| Ensembl ID | ENSG00000155508 |
| Bio databases IDs | |
| Aliases | CCR4-NOT transcription complex subunit 8, PGK promoter directed over production |
| Synonyms | 1500015I04Rik, 1810022F04Rik, CAF1, Caf1b, CALIF, CCR4-NOT transcription complex subunit 8, CCR4-NOT transcription complex, subunit 8, hCAF1, POP2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CNOT8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3'-5' exoribonuclease
- transcription regulator
- poly(A)-specific ribonuclease
- CAF1 family ribonuclease
- catalytic domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CNOT8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- positive regulation of mRNA catabolic process
- positive regulation of cell proliferation
- mRNA cleavage involved in gene silencing by miRNA
- nuclear-transcribed mRNA poly(A) tail shortening
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- cytoplasmic mRNA processing body
- CCR4-NOT core complex
- CCR4-NOT complex
Molecular Function
What the gene product does at the molecular level
- poly(A)-specific ribonuclease activity
- 3'-5'-exoribonuclease activity
- protein binding
- RNA binding
- metal ion binding