CNOT2 Gene Summary [Human]
This gene encodes a subunit of the multi-component CCR4-NOT complex. The CCR4-NOT complex regulates mRNA synthesis and degradation and is also thought to be involved in mRNA splicing, transport and localization. The encoded protein interacts with histone deacetylases and functions as a repressor of polymerase II transcription. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Details
| Type | Protein Coding |
| Official Symbol | CNOT2 |
| Official Name | CCR4-NOT transcription complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:7878] |
| Ensembl ID | ENSG00000111596 |
| Bio databases IDs | |
| Aliases | CCR4-NOT transcription complex subunit 2, CC chemokine receptor 4-negative regulator of transcription 2 |
| Synonyms | 2600016M12Rik, 2810470K03RIK, CCR4-NOT transcription complex subunit 2, CCR4-NOT transcription complex, subunit 2, CDC36, HSPC131, IDNADFS, LOC100128679, NOT2, NOT2H |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CNOT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- NOT2 / NOT3 / NOT5 family
- poly(A)-specific ribonuclease
- transcription cofactor
- transcription factor binding
- protein binding
- NOT-box domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- intellectual developmental disorder with nasal speech, dysmorphic facies, and variable skeletal anomalies
- neurodevelopmental disorder
- breast cancer
- ovarian carcinoma
- epithelial ovarian cancer
- amyotrophic lateral sclerosis
- tumorigenesis
regulated by
regulates
- reporter gene
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
role in cell
- apoptosis
- assembly
- growth
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CNOT2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of translation
- positive regulation of cytoplasmic mRNA processing body assembly
- regulation of stem cell maintenance
- gene silencing by RNA
- negative regulation of intracellular estrogen receptor signaling pathway
- trophectodermal cell differentiation
- nuclear-transcribed mRNA poly(A) tail shortening
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytoplasmic mRNA processing body
- cytosol
- CCR4-NOT core complex
- CCR4-NOT complex
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- poly(A)-specific ribonuclease activity
- transcription cofactor activity
- protein binding