BTG1 Gene Summary [Human]
This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]
Details
| Type | Protein Coding |
| Official Symbol | BTG1 |
| Official Name | BTG anti-proliferation factor 1 [Source:HGNC Symbol;Acc:HGNC:1130] |
| Ensembl ID | ENSG00000133639 |
| Bio databases IDs | |
| Aliases | BTG anti-proliferation factor 1 |
| Synonyms | AI426953, APRO2, BTG anti-proliferation factor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BTG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BTG family
- transcription regulator
- LXXLL motif
- enzyme binding
- protein binding
- BoxC domain
- Box B domain
- phosphorylation site
- tob/btg1 family
Pathways
Biological processes and signaling networks where the BTG1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- peripheral T-cell lymphoma
- advanced cancer
- insulin resistance
- major depression
- duodenal-type follicular lymphoma
- follicular non-Hodgkin disease
- duodenal cancer
- limited-stage typical follicular lymphoma
- precursor B-cell acute lymphoblastic leukemia
role in cell
- expression in
- apoptosis
- cell death
- growth
- signaling in
- proliferation
- differentiation
- dissemination
- motility
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BTG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- negative regulation of cell growth
- negative regulation of cell proliferation
- positive regulation of fibroblast apoptotic process
- regulation of transcription, DNA-dependent
- negative regulation of mitotic cell cycle
- positive regulation of myoblast differentiation
- positive regulation of endothelial cell differentiation
- cell migration
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity
- kinase binding
- enzyme binding