CARNMT1 Gene Summary [Human]
The protein encoded by this gene is a methyltransferase that converts carnosine to anserine, a dipeptide found abundantly in skeletal muscle. The encoded protein can methylate other dipeptides as well. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | CARNMT1 |
| Official Name | carnosine N-methyltransferase 1 [Source:HGNC Symbol;Acc:HGNC:23435] |
| Ensembl ID | ENSG00000156017 |
| Bio databases IDs | |
| Aliases | carnosine N-methyltransferase 1 |
| Synonyms | 2410127L17Rik, C9orf41, carnosine N-methyltransferase 1, RGD1311863, UPF0586 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CARNMT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carnosine N-methyltransferase
- protein homodimerization
- enzyme
- protein binding
- AdoMet_MTases
- S-adenosylmethionine-dependent methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CARNMT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carnosine metabolic process
- histidine catabolic process
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- carnosine N-methyltransferase activity
- protein homodimerization activity
- protein binding
- S-adenosylmethionine-dependent methyltransferase activity