TNFRSF10A Gene Summary [Human]
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TNFRSF10A |
| Official Name | TNF receptor superfamily member 10a [Source:HGNC Symbol;Acc:HGNC:11904] |
| Ensembl ID | ENSG00000104689 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 10a |
| Synonyms | APO2, CD261, Death receptor 4, DR4, TNF receptor superfamily member 10a, TR1, TRAIL-R1, TRAIL receptor-1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFRSF10A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- extracellular domain
- death receptor
- protease binding
- TNFR/NGFR cysteine-rich region
- protein binding
- identical protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- cytoplasmic domain
- ligand-binding domain
- intracellular domain
- cytosolic tail domain
- membrane-proximal domain
- Death Domain Superfamily of protein-protein interaction domains
- transmembrane receptor
Pathways
Biological processes and signaling networks where the TNFRSF10A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- chronic lymphocytic leukemia
- rheumatoid arthritis
- ovarian cancer
- mantle cell lymphoma
- osteoarthritis
- spondylarthritis
- non-Hodgkin disease
- metastatic breast cancer
- pancreatic carcinoma
role in cell
- cell viability
- proliferation
- apoptosis
- expression in
- phosphorylation in
- growth
- cell death
- necrosis
- transmembrane potential
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- Golgi Apparatus
- cytosol
- nuclear rim
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFRSF10A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to mechanical stimulus
- signal transduction
- activation of NF-kappaB-inducing kinase activity
- positive regulation of apoptotic process
- apoptotic process
- extrinsic apoptotic signaling pathway
- induction of apoptosis via death domain receptors
Cellular Component
Where in the cell the gene product is active
- membrane raft
- cytosol
- Golgi apparatus
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- signaling receptor activity
- protease binding
- death receptor activity
- TRAIL binding