FUT6 Gene Summary [Human]
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | FUT6 |
| Official Name | fucosyltransferase 6 [Source:HGNC Symbol;Acc:HGNC:4017] |
| Ensembl ID | ENSG00000156413 |
| Bio databases IDs | |
| Aliases | fucosyltransferase 6, alpha-(1,3)-fucosyltransferase, galactoside 3-L-fucosyltransferase |
| Synonyms | FCT3A, FT1A, fucosyltransferase 6, Fuc-TVI |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FUT6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase
- alpha(1,3)-fucosyltransferase
- Fucosyltransferase, N-terminal
- fucosyltransferase
- enzyme
- Glycosyltransferase family 10 (fucosyltransferase) C-term
- galactoside 3-fucosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- metastasis
- prostate cancer
- age-related macular degeneration
- fucosyltransferase 6 deficiency
role in cell
- apoptosis
- phosphorylation in
- activation in
- synthesis in
- activation
- adhesion
- cell rolling
- breaching by
- dimerization in
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Golgi Apparatus
- Golgi membrane
- Weibel-Palade bodies
- plasma
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FUT6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oocyte axis specification
- protein O-linked glycosylation
- protein glycosylation
- protein N-linked glycosylation
- N-glycan fucosylation
- oligosaccharide biosynthetic process
- L-fucose catabolic process
- ceramide metabolic process
- glycosphingolipid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- methylosome
- Golgi cisterna membrane
- Golgi apparatus
- Golgi membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
- fucosyltransferase activity
- alpha-(1->3)-fucosyltransferase activity