SH3GLB1 Gene Summary [Human]
This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | SH3GLB1 |
| Official Name | SH3 domain containing GRB2 like, endophilin B1 [Source:HGNC Symbol;Acc:HGNC:10833] |
| Ensembl ID | ENSG00000097033 |
| Bio databases IDs | |
| Aliases | SH3 domain containing GRB2 like, endophilin B1, protein phosphatase 1, regulatory subunit 70 |
| Synonyms | AU015566, Bif-1, CGI-61, dJ612B15.2, endophilin B1, mKIAA0491, PPP1R70, SH3 domain -containing GRB2-like endophilin B1, SH3 domain containing GRB2 like, endophilin B1, SH3-domain GRB2-like B1 (endophilin) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SH3GLB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lysophosphatidic acid acyltransferase
- fatty acid binding
- protein homodimerization
- enzyme
- BAR domain
- phosphoinositide 3-kinase regulator
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the SH3GLB1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- primary melanoma
- melanoma cancer
- primary cancer
- organismal death
- mucopolysaccharidosis type IVB
- lymphocytic cancer
- survival
- astrocytosis
- melanoma
role in cell
- expression in
- proliferation
- signaling in
- depolarization
- cell death
- production in
- apoptosis
- activation in
- tubulation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- mitochondrial envelope
- cellular membrane
- Mitochondria
- midbody
- cytosol
- nuclear bodies
- synaptic vesicles
- autophagic vacuoles
- early endosomes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SH3GLB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane organization
- membrane fission
- cellular response to amino acid starvation
- cellular response to glucose starvation
- positive regulation of autophagy
- receptor catabolic process
- regulation of protein stability
- autophagy
- autophagic cell death
- apoptotic process
- regulation of macroautophagy
- regulation of cytokinesis
- positive regulation of autophagic vacuole assembly
- positive regulation of protein complex assembly
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytoplasmic vesicle
- cytosol
- macromolecular complex
- Golgi membrane
- midbody
- mitochondrial outer membrane
- autophagic vacuole membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- cadherin binding
- lipid binding