MTERF3 Gene Summary [Human]
Enables transcription cis-regulatory region binding activity. Involved in negative regulation of transcription, DNA-templated. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MTERF3 |
| Official Name | mitochondrial transcription termination factor 3 [Source:HGNC Symbol;Acc:HGNC:24258] |
| Ensembl ID | ENSG00000156469 |
| Bio databases IDs | |
| Aliases | mitochondrial transcription termination factor 3 |
| Synonyms | 2410017I18Rik, CGI-12, mitochondrial transcription termination factor 3, MTERFD1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MTERF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- double-stranded DNA binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- organismal death
- epithelial cancer
- liver cancer
- growth failure
regulates
- adenosine triphosphate
- reactive oxygen species
- p38 MAPK
role in cell
- phosphorylation in
- apoptosis
- proliferation
- late S/G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MTERF3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from mitochondrial promoter
- negative regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription regulatory region sequence-specific DNA binding