RXRA Gene Summary [Human]
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Details
| Type | Retained Intron |
| Official Symbol | RXRA |
| Official Name | retinoid X receptor alpha [Source:HGNC Symbol;Acc:HGNC:10477] |
| Ensembl ID | ENSG00000186350 |
| Bio databases IDs | |
| Aliases | retinoid X receptor alpha, nuclear receptor subfamily 2 group B member 1 |
| Synonyms | 9530071D11RIK, LOC101928454, NR2B1, retinoid 10 receptor α, Retinoid X receptor alpha, Retinoid X receptor α, RXR-alpha, RXRalpha1, RXR-α, Rxr α 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RXRA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptide binding
- steroid hormone receptor
- A/B region
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- retinoic acid receptor binding
- transcription activation domain
- transcription factor binding
- AF-2 transcription activation domain
- chromatin binding
- TA box
- retinoid binding
- identical protein binding
- hormone binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- nuclear receptor ligand binding domain
- P-box
- AF-1 domain
- zinc ion binding
- ligand-binding domain
- ligand-dependent nuclear receptor
- RXRalpha ABC domain
- T-box domain
- Jnk phosphorylation site
- dimerization domain
- DBD domain binding
- DNA binding domain
- nucleic acid binding
- vitamin D receptor binding
- enzyme binding
- protein domain specific binding
- protein binding
- thyroid hormone receptor binding
- LBD domain binding
- sequence-specific DNA binding
- DNA binding
- phosphorylation site
- Nuclear/hormone receptor activator site AF-1
- binding protein
- double-stranded DNA binding
- hinge domain
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the RXRA gene in human plays a role, providing insight into its function and relevance in health or disease.
- Adrenomedullin signaling pathway
- Aryl Hydrocarbon Receptor Signaling
- Docosahexaenoic Acid (DHA) Signaling
- FXR/RXR Activation
- Glucocorticoid Receptor Signaling
- Hepatic Cholestasis
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Non-Small Cell Lung Cancer Signaling
- Nur77 Signaling in T Lymphocytes
- PPAR Signaling
- PPARα/RXRα Activation
- PXR/RXR Activation
- RAR Activation
- Retinoic acid Mediated Apoptosis Signaling
- Small Cell Lung Cancer Signaling
- TR/RXR Activation
- VDR/RXR Activation
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- epithelial cancer
- cancer
- neoplasia
- plasma cell myeloma
- skin cancer
- eczema
- retinitis pigmentosa
- type M3 acute myeloid leukemia
- acne vulgaris
role in cell
- cell viability
- growth
- apoptosis
- expression in
- activation in
- proliferation
- production in
- invasion by
- migration
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- membrane fraction
- Cytoplasm
- perinuclear region
- Mitochondria
- cytosol
- nucleoplasm
- interchromatin granule clusters
- chromatin
- axons
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RXRA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- anatomical structure development
- positive regulation of transcription from RNA polymerase II promoter
- steroid hormone mediated signaling pathway
- hormone-mediated signaling pathway
- positive regulation of thyroid hormone mediated signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- response to retinoic acid
- retinoic acid receptor signaling pathway
- positive regulation of transcription, DNA-dependent
- positive regulation of cholesterol efflux
- cell differentiation
- positive regulation of transporter activity
- positive regulation of vitamin D receptor signaling pathway
- peroxisome proliferator activated receptor signaling pathway
- positive regulation of bone mineralization
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- mitochondrion
- cytosol
- receptor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- double-stranded DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- peptide binding
- sequence-specific DNA binding
- retinoic acid-responsive element binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- retinoic acid binding
- transcription cofactor binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- DBD domain binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- LBD domain binding
- vitamin D response element binding
- vitamin D receptor binding
- steroid hormone receptor activity
- enzyme binding