C12orf43 Gene Summary [Human]
Predicted to be involved in Spemann organizer formation and negative regulation of Wnt signaling pathway. Predicted to be located in nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | C12orf43 |
| Official Name | chromosome 12 open reading frame 43 [Source:HGNC Symbol;Acc:HGNC:25719] |
| Ensembl ID | ENSG00000157895 |
| Bio databases IDs | |
| Aliases | chromosome 12 open reading frame 43 |
| Synonyms | 2210016L21Rik, C12h12orf43, C12orf43l, chromosome 12 open reading frame 43, Custos, RGD1311899, RIKEN cDNA 2210016L21 gene, similar to human chromosome 12 open reading frame 43 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human C12orf43 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human C12orf43 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- Spemann organizer formation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
Molecular Function
What the gene product does at the molecular level
- protein binding