YEATS4 Gene Summary [Human]
The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
Details
| Type | Protein Coding |
| Official Symbol | YEATS4 |
| Official Name | YEATS domain containing 4 [Source:HGNC Symbol;Acc:HGNC:24859] |
| Ensembl ID | ENSG00000127337 |
| Bio databases IDs | |
| Aliases | YEATS domain containing 4 |
| Synonyms | 4930573H17Rik, B230215M10Rik, GAS41, NUBI-1, RGD1305741, YAF9, YEATS domain containing 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human YEATS4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- YEATS domain
- YEATS domain family, chromatin reader proteins
- histone binding
- transcription regulator
- ENL/AF9-like domain
- protein binding activity, bridging
- coiled-coil domain
- protein binding
- YEATS family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- heart failure
- lung adenocarcinoma
- lung adenocarcinoma formation
- endometrium tumor
- neoplastic cell transformation
- uterine leiomyoma
- leiomyomatosis
role in cell
- expression in
- cell death
- proliferation
- quantity
- survival
- colony formation
- number
- growth
- senescence
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleosomes
- nucleoplasm
- nucleoli
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human YEATS4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- cytoskeleton organization
- regulation of double-strand break repair
- positive regulation of transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- regulation of apoptotic process
- regulation of cell cycle
- mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- NuA4 histone acetyltransferase complex
- nuclear matrix
- nucleosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- histone acetyl-lysine binding
- structural constituent of cytoskeleton