SNAP29 Gene Summary [Human]

This gene, a member of the SNAP25 gene family, encodes a protein involved in multiple membrane trafficking steps. Two other members of this gene family, SNAP23 and SNAP25, encode proteins that bind a syntaxin protein and mediate synaptic vesicle membrane docking and fusion to the plasma membrane. The protein encoded by this gene binds tightly to multiple syntaxins and is localized to intracellular membrane structures rather than to the plasma membrane. While the protein is mostly membrane-bound, a significant fraction of it is found free in the cytoplasm. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
SNAP29
Official Name
synaptosome associated protein 29 [Source:HGNC Symbol;Acc:HGNC:11133]
Ensembl ID
ENSG00000099940
Bio databases IDs NCBI: 9342 Ensembl: ENSG00000099940
Aliases synaptosome associated protein 29, soluble 29 kDa NSF attachment protein, cerebral dysgenesis, neuropathy, ichthyosis and keratoderma syndrome
Synonyms 1300018G05Rik, CEDNIK, Gs32, synaptosomal-associated protein 29, synaptosome associated protein 29
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SNAP29 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • SNAP receptor
  • Helical region found in SNAREs
  • coiled-coil domain
  • protein binding
  • SNARE motif
  • syntaxin binding

Pathways

Biological processes and signaling networks where the SNAP29 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • human papilloma virus infection
  • cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome, cednik syndrome
  • hereditary disorder
  • Pelizaeus-Merzbacher-like disease
  • Duchenne muscular dystrophy
  • oral cancer
regulated by
regulates
role in cell
  • killing
  • degradation in
  • synaptic transmission
  • production in
  • expression in
  • proliferation
  • number
  • replication in
  • attachment
  • trafficking

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytosolic synaptosomal fraction
  • plasma membrane fraction
  • membrane fraction
  • cilia
  • cellular membrane
  • Plasma Membrane
  • vesicles
  • centrosome
  • Golgi Apparatus
  • Mitochondria
  • secretory granule membrane
  • cytosol
  • Golgi membrane
  • lysosome membrane
  • synaptic vesicles
  • growth cone
  • neurites
  • synapse
  • autophagic vacuoles
  • perikaryon
  • axons
  • dendrites
  • synaptic vesicle fractions

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SNAP29 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • membrane fusion
  • synaptic vesicle priming
  • cilium morphogenesis
  • vesicle targeting
  • synaptic vesicle fusion to presynaptic membrane
  • protein transport
  • autophagic vacuole docking
  • exocytosis

Cellular Component

Where in the cell the gene product is active
  • centrosome
  • cytoplasm
  • cytosol
  • SNARE complex
  • Golgi membrane
  • flagellar pocket membrane
  • azurophil granule membrane
  • autophagic vacuole membrane
  • plasma membrane
  • autophagic vacuole

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • syntaxin binding
  • SNAP receptor activity

Gene-Specific Assays for Results You Can Trust

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